Spontaneous Cryptococcal Peritonitis Successfully Treated with Fluconazole

Spontaneous cryptococcal peritonitis is an uncommon infection that predominantly encountered in immunocompromised. Its clinical presentation is indistinguishable from spontaneous bacterial peritonitis and often results in fatal outcome. Liver disease is an under recognized predisposition for cryptococcal disease. We report a case of spontaneous cryptococcal peritonitis in HIV-negative, non-diabetic female patient with chronic hepatitis C related cirrhosis. Cryptococcus infection was diagnosed by India ink and culture of ascetic fluid. The patient was successfully treated with fluconazole and she was well at the follow up of 9 months. Early clinical suspicion and initiation of antifungal are of paramount to save the patient’s life.